α-Amination of Nitrogen Heterocycles:  Ring-Fused Aminals

Zhang, Chen; De, Chandra Kanta; Mal, Rudrajit; Seidel, Daniel

doi:10.1021/ja077473r.s004

ja077473r_si_004.pdf (2.23 MB)

α-Amination of Nitrogen Heterocycles: Ring-Fused Aminals

journal contribution

posted on 2008-01-16, 00:00 authored by Chen Zhang, Chandra Kanta De, Rudrajit Mal, Daniel Seidel

Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process is applied to two-step syntheses of the quinazolinone alkaloids deoxyvasicinone and rutaecarpine.

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Keywords

Aromatic Heterocycle aminoaldehyde Amination Aminal synthese aminal rutaecarpine quinazolinone alkaloids deoxyvasicinone cyclic amines

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