ol7b00914_si_001.pdf (5.38 MB)
[3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2‑Alkenylindoles: An Approach to Tetrahydro-β-carbolinones
journal contribution
posted on 2017-05-09, 18:09 authored by Kaifan Zhang, Xiaoying Xu, Jiuan Zheng, Hequan Yao, Yue Huang, Aijun LinA novel
[3 + 3] cycloaddition between in situ formed azaoxyallyl
cations and 2-alkenylindoles has been developed. This concise method
allows the efficient construction of a series of tetrahydro-β-carbolinones
in good yields under mild conditions. Gram-scale experiments and further
derivatization of tetrahydro-β-carbolinones highlighted the
potential utility of our method.