ol901435k_si_001.pdf (8.4 MB)
Zn(II)-Catalyzed Synthesis of Piperidines from Propargyl Amines and Cyclopropanes
journal contribution
posted on 2009-08-20, 00:00 authored by Terry P. Lebold, Andrew B. Leduc, Michael A. KerrThe reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf2)2 allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia−ene cyclization.