posted on 2020-03-24, 13:07authored byXinting Cheng, Zhou Zhu, Yanhua Liu, Yiyuan Xue, Xiaomeng Gao, Jian Wang, Xibo Pei, Qianbing Wan
Bisphosphonates
(BPs) are routinely administered for the treatment
of turnover bone diseases. To avoid the undesirable adverse effects
of long-term usage of bisphosphonates and improve their bioavailability
in the bone microenvironment, we initially encapsulated risedronate
(RIS) molecules inside nanoscale zeolitic imidazolate framework-8
particles (nZIF-8) by a one-step synthesis method to generate RIS@ZIF-8
nanoparticles. RIS@ZIF-8 nanoparticles displayed high loading encapsulation
efficiency (64.21 ± 2.48%), good biocompatibility, controlled
drug release capacity, and dual effects for bone regeneration. This
work explored the potential of RIS@ZIF-8 nanoparticles, which could
not only enhance ATP production, induce extracellular matrix (ECM)
mineralization, and upregulate the expression levels of osteogenic
genes but also effectively inhibit the formation of multinucleated
giant osteocasts and decrease the Rankl/Opg ratio. Overall, RIS@ZIF-8
nanoparticles could be a very promising approach to synergistically
enhance osteogenic and antiresorptive properties for bone regeneration,
which could be utilized for the local treatment of bone defects.