jp9b11043_si_001.pdf (1.15 MB)
Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications
journal contribution
posted on 2020-03-11, 20:19 authored by Przemyslaw Kowalik, Jakub Mikulski, Anna Borodziuk, Magdalena Duda, Izabela Kamińska, Karolina Zajdel, Jaroslaw Rybusinski, Jacek Szczytko, Tomasz Wojciechowski, Kamil Sobczak, Roman Minikayev, Magdalena Kulpa-Greszta, Robert Pazik, Paulina Grzaczkowska, Krzysztof Fronc, Mariusz Lapinski, Małgorzata Frontczak-Baniewicz, Bozena SikoraMagnetic
nanoparticles of Fe3O4 doped by
different amounts of Y3+ (0, 0.1, 1, and 10%) ions were
designed to obtain maximum heating efficiency in magnetic hyperthermia
for cancer treatment. Single-phase formation was evident by X-ray
diffraction measurements. An improved magnetization value was obtained
for the Fe3O4 sample with 1% Y3+ doping.
The specific absorption rate (SAR) and intrinsic loss of power (ILP)
values for prepared colloids were obtained in water. The best results
were estimated for Fe3O4 with 0.1% Y3+ ions (SAR = 194 W/g and ILP = 1.85 nHm2/kg for a magnetic
field of 16 kA/m with the frequency of 413 kHz). The excellent biocompatibility
with low cell cytotoxicity of Fe3O4:Y nanoparticles
was observed. Immediately after magnetic hyperthermia treatment with
Fe3O4:0.1%Y, a decrease in 4T1 cells’
viability was observed (77% for 35 μg/mL and 68% for 100 μg/mL).
These results suggest that nanoparticles of Fe3O4 doped by Y3+ ions are suitable for biomedical applications,
especially for hyperthermia treatment.