ao8b02523_si_001.pdf (1.26 MB)
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
journal contribution
posted on 2019-01-18, 18:39 authored by Martin Fries, Meike Mertens, Nico Teske, Markus Kipp, Cordian Beyer, Thomas Willms, Arto Valkonen, Kari Rissanen, Markus Albrecht, Tim ClarnerThe
cuprizone mouse model is one of the most accepted model systems
for the investigation of oligodendrocyte degeneration, a process critically
involved in the pathogenesis of diseases such as multiple sclerosis
or schizophrenia. In order to substitute the in vivo experiments by
in vitro approaches, the amine derivative BiMPi is introduced as a
water-soluble alternative to cuprizone. Regarding superoxide dismutase
activity, toxicity for oligodendrocytes, and disturbance of mitochondrial
membrane potential, BiMPi shows similar in vitro effects as is observed
in vivo for cuprizone.