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Visualizing Fluoride Ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes
journal contribution
posted on 2015-09-01, 00:00 authored by Zhisheng Wu, Xinjing TangTwo ratiometric probes fluoride ion, Mito-F and Lyso-F, were rationally designed and
synthesized with positive
charges at physiological conditions. The positive charges functioned
as target moieties for subcellular mitochondria and lysosome of living
cells, and effective sequesters of fluoride ion for fast and efficient
fluorescent detection. In addition, in vivo imaging of fluoride ion
in living mice was successfully achieved for the first time using
probe Mito-F.