ol5b03705_si_001.pdf (17.38 MB)
Visible Light Photoredox Cross-Coupling of Acyl Chlorides with Potassium Alkoxymethyltrifluoroborates: Synthesis of α‑Alkoxyketones
journal contribution
posted on 2016-02-01, 00:00 authored by Javad Amani, Esmat Sodagar, Gary A. MolanderA visible-light,
single-electron-transfer (SET), photoredox cross-coupling
for the synthesis of α-alkoxyketones has been developed. In
this method, various aliphatic and aromatic acyl chlorides were successfully
coupled with structurally diverse potassium alkoxymethyltrifluoroborates,
producing the corresponding α-alkoxyketones with high yields.
In this operationally simple and mild cross-coupling protocol, the
desired ketones are obtained in one step from bench stable starting
materials by a bond connection that is unique to both alkylboron chemistry
and photoredox/Ni catalysis.