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Vicinal Bisheterocyclizations of Alkynes via Nucleophilic Interception of a Catalytic Platinum Carbene
journal contribution
posted on 2013-11-20, 00:00 authored by Paul A. Allegretti, Eric M. FerreiraA novel platinum-catalyzed double
heterocyclization of propargylic ethers is described. The transformation
exploits the intermediacy of a key α,β-unsaturated carbene.
The reactivity of this carbene is such that systems can be developed
which avoid a complicating 1,2-hydrogen migration, allowing remarkable
versatility in the selective syntheses of oxygen- and nitrogen-containing
vicinal bis-heterocyclic compounds.