cm401807m_si_001.pdf (735.94 kB)
Using Evaporation-Induced Self-Assembly for the Direct Drug Templating of Therapeutic Vectors with High Loading Fractions, Tunable Drug Release, and Controlled Degradation
journal contribution
posted on 2013-12-10, 00:00 authored by Thomas Fontecave, Cedric Boissiere, Niki Baccile, Francisco
J. Plou, Clement SanchezA novel one-step approach for designing
nonaggregated silica-based
mesostructured therapeutic vectors is presented. Evaporation-induced
self-assembly was used in combination with amphiphilic drugs for preparing
already loaded class I and class II hybrid materials containing from
50 to 60 wt % (up to 75 vol %) of three drugs (glucosyl-resveratrol,
stearoyl choline, sophorolipid). A good mesostructuration was able
to promote an interfacial control of the drug release in PBS medium.
The investigation of both release mechanisms and matrix dissolution
was conducted via in situ ellipsometry and NMR. It proved that the
nature of the drug/matrix interaction, the chemical composition of
the drug/matrix interface, and the mesostructuration quality parameters
must be taken into account at the same time for tuning the drug release
rate, while maintaining the dissolution rate of silica at a reasonable
level for limiting its toxicity. It proved also that noncalcined as-made
silica-based class I hybrid materials can be efficiently used for
tuning drug release kinetics from 1 h to day scale.
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stearoyl cholineclass IITunable Drug ReleaseTherapeutic Vectorschemical compositiondrug releaseNMRControlled DegradationA novelPBS mediummesostructuration quality parametersmatrix dissolutionHigh Loading FractionsDirect Drug Templatingdrug release kineticsday scaleamphiphilic drugs1 hdissolution raterelease mechanismsdrug release rate
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