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Universal Strategy for Efficient Fabrication of Blood Compatible Surfaces via Polydopamine-Assisted Surface-Initiated Activators Regenerated by Electron Transfer Atom-Transfer Radical Polymerization of Zwitterions
journal contribution
posted on 2020-02-25, 19:46 authored by Nan Li, Tong Li, Xin-Yu Qiao, Rong Li, Yao Yao, Yong-Kuan GongImplant
and blood-contacting biomaterials are challenged by biofouling
and thrombus formation at their interface. Zwitterionic polymer brush
coating can achieve excellent hemocompatibility, but the preparation
often involves tedious, expensive, and complicated procedures that
are designed for specific substrates. Here, we report a facile and
universal strategy of creating zwitterionic polymer brushes on variety
of materials by polydopamine (PDA)-assisted and surface-initiated
activators regenerated by electron transfer atom-transfer radical
polymerization (PDA-SI-ARGET-ATRP). A PDA adhesive layer is first
dipcoated on a substrate, followed by covalent immobilization of 3-trimethoxysilyl
propyl 2-bromo-2-methylpropionate (SiBr, ATRP initiator) on the PDA
via condensation. Meanwhile, the trimethoxysilyl group of SiBr also
cross-links the PDA oligomers forming stabilized PDA/SiBr complex
coating. Finally, SI-ARGET-ATRP is performed in a zwitterionic monomer
solution catalyzed by the parts per million level of CuBr2 without deoxygenization. The conveniently fabricated zwitterionic
polymer brush coatings are demonstrated to have stable, ultralow fouling,
and extremely blood compatible and functionalizable characteristics.
This facile, versatile, and universal surface modification strategy
is expected to be widely applicable in various advanced biomaterials
and devices.
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Efficient Fabricationblood-contacting biomaterialsElectron Transfer Atom-Transfer Radical Polymerizationzwitterionic monomer solutionsubstrateelectron transfer atom-transferzwitterionic polymer brushesZwitterions Implantzwitterionic polymer brush coatingsPolydopamine-Assisted Surface-Initiated Activators Regeneratedcovalent immobilizationUniversal Strategy3- trimethoxysilyl propyl 2- bromo -2-methylpropionateZwitterionic polymer brush coatingsurface-initiated activators regeneratedfunctionalizable characteristicsSI-ARGET-ATRPPDA oligomerssurface modification strategyCuBr 2Blood Compatible Surfacesthrombus formationPDA-SI-ARGET-ATRPATRP initiatortrimethoxysilyl groupSiBrultralow fouling
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