ac9b02630_si_001.pdf (653.2 kB)
Ultrasensitive Detection of Human Chorionic Gonadotropin Using Frequency Locked Microtoroid Optical Resonators
journal contribution
posted on 2019-08-23, 19:16 authored by Erol Ozgur, Kara Ellen Roberts, Ekin Ozge Ozgur, Adley Nathanael Gin, Jaden Robert Bankhead, Zhikun Wang, Judith SuClean
sport competition is of significant concern to many governments
and sporting organizations. Highly sensitive and rapid sensors are
needed to improve the detection of performance enhancing drugs in
sports as athletes take diuretics to dilute the concentration of drugs
in their urine and microdose under the detectable limits of current
sensors. Here we demonstrate, using frequency locked microtoroid optical
resonators, a 3 orders of magnitude improvement in detection limit
over the current gold standard, mass spectrometry, for the common
performance enhancing drug, human chorionic gonadotropin (hCG). hCG,
also known as the pregnancy hormone, was detected both in simulated
urine and in the urine of pregnant donors at a concentration of 1
and 3 femtomolar, respectively. We anticipate that the sensitivity
provided by frequency locked optical microcavities can enable a new
standard in antidoping research.