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Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets
journal contribution
posted on 2019-05-28, 00:00 authored by Wei Jiang, Zhen Zhang, Qin Wang, Jiaxiang Dou, Yangyang Zhao, Yinchu Ma, Huarong Liu, Hangxun Xu, Yucai WangBoth
diffusion-limited and perfusion-limited hypoxia are associated
with tumor progression, metastasis, and the resistance to therapeutic
modalities. A strategy that can efficiently overcome both types of
hypoxia to enhance the efficacy of cancer treatment has not been reported
yet. Here, it is shown that by using biomimetic ultrathin graphdiyne
oxide (GDYO) nanosheets, both types of hypoxia can be simultaneously
addressed toward an ideal photodynamic therapy (PDT). The GDYO nanosheets,
which are oxidized and exfoliated from graphdiyne (GDY), are able
to efficiently catalyze water oxidation to release O2 and
generate singlet oxygen (1O2) using near-infrared
irradiation. Meanwhile, GDYO nanosheets also exhibit excellent light-to-heat
conversion performance with a photothermal conversion efficiency of
60.8%. Thus, after the GDYO nanosheets are coated with iRGD peptide-modified
red blood membrane (i-RBM) to achieve tumor targeting, the biomimetic
GDYO@i-RBM nanosheets can simultaneously enhance tumor reoxygenation
and blood perfusion for PDT. This study provides new insights into
utilizing novel water-splitting materials to relieve both diffusion-
and perfusion-limited hypoxia for the development of a novel therapeutic
platform.
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Blood Perfusion Enhanced Photodynamic Therapybiomimetic ultrathin graphdiyne oxidephotothermal conversion efficiencyperfusion-limited hypoxiacatalyze water oxidationtumorUltrathin Graphdiyne Oxide NanosheetstypePDT1 O 2release O 2novel water-splitting materialsGDYO nanosheetslight-to-heat conversion performance
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