ol6b00195_si_001.pdf (1.96 MB)
Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes
journal contribution
posted on 2016-02-24, 00:00 authored by Aitziber Irastorza, Jesús M. Aizpurua, Arkaitz CorreaSelective
Pd-catalyzed C(sp2)–H oxygenation of
4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed
C–H functionalization events, which preferentially occur at
the activated heterocyclic C–H bond, the regioselective oxygenation
of the arene/alkene moiety is now achieved featuring the unconventional
role of a simple triazole scaffold as a modular and selective directing
group.