Transition-Metal-Free Oxidative Aminooxyarylation of Alkenes: Annulations toward Aminooxylated Oxindoles
2018-02-03T19:29:29Z (GMT) by
An efficient oxidative aminooxyarylation of alkenes under a transition-metal-free condition was described. Under the reaction conditions, <i>N</i>-hydroxyphthalimide (NHPI) reacted readily with <i>N</i>-arylacrylamides to produce cyclic products via a radical C–H functionalization process, achieving both C–O and C–C bonds formation in one pot. This reaction provided a facile access to the valuable aminooxylated oxindoles. The benzylic and α-methylene C(sp<sup>3</sup>)-H bonds were also aminooxylated under the reaction conditions.
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