nl9b05008_si_002.avi (15.06 MB)
Transforming Complexity to Simplicity: Protein-Like Nanotransformer for Improving Tumor Drug Delivery Programmatically
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posted on 2020-02-24, 16:33 authored by Hui Xiong, Zihan Wang, Cheng Wang, Jing YaoIt was difficult
for nanodrugs to simultaneously meet the contradictory
requirements of prolonged circulation time, augmented cellular uptake,
rapid lysosome escape, precise drug release, and tumor penetration
in tumor drug delivery. We prepared a nanotransformer (DTIG) through
assembling doxorubicin, tannic acid, and indocyanine green to overcome
this dilemma. Hydrophilic DTIG showed prolonged blood circulation
time. Besides, DTIG could be efficiently internalized by tumor cells
through transforming into hydrophobic particles in an acidic tumor
microenvironment. Subsequently, oversized hydrophobic particles were
further formed in acidic lysosomes to escape from it through rupturing
the lysosome. These hydrophobic DTIGs could rapidly revert to a smaller
hydrophilic nanoassembly and release the payloads in cytoplasm. Similar
to denaturation and renaturation of protein, these high-efficiency
instantaneous transformations were activated by proton. Besides, photothermal
therapy of DTIG promoted drug penetration efficiency in tumor. This
optimized drug delivery process of DTIG finally offered potent antitumor
efficacy and an obvious advantage on prognosis.
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acidic tumor microenvironmentantitumor efficacytumor drug deliverydrug releasephotothermal therapyTransforming Complexityoptimized drug delivery processdrug penetration efficiencytannic acidblood circulation timeProtein-Like NanotransformerTumor Drug Delivery Programmaticallycirculation timeacidic lysosomestumor penetrationHydrophilic DTIGtumor cells
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