Total Synthesis of (−)-Secu’amamine A Exploiting Type II Anion Relay Chemistry
2015-09-04T00:00:00Z (GMT)
by
A total
synthesis of (−)-secu’amamine A has been
achieved exploiting Type II Anion Relay Chemistry (ARC) to provide
the full linear carbon and nitrogen skeleton in a single flask with
the requisite stereochemistry and functionality. A mechanistic rationale
is also proposed to account for the stereochemical outcome of the
key aldol reaction leading to the advanced aza tricyclic core.
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CC BY-NC 4.0