ol5b02018_si_001.pdf (2.88 MB)
Total Synthesis of (−)-Secu’amamine A Exploiting Type II Anion Relay Chemistry
journal contribution
posted on 2015-09-04, 00:00 authored by Heeoon Han, Amos B. SmithA total
synthesis of (−)-secu’amamine A has been
achieved exploiting Type II Anion Relay Chemistry (ARC) to provide
the full linear carbon and nitrogen skeleton in a single flask with
the requisite stereochemistry and functionality. A mechanistic rationale
is also proposed to account for the stereochemical outcome of the
key aldol reaction leading to the advanced aza tricyclic core.