Total Synthesis of (−)-Secu’amamine A Exploiting Type II Anion Relay Chemistry

2015-09-04T00:00:00Z (GMT) by Heeoon Han Amos B. Smith
A total synthesis of (−)-secu’amamine A has been achieved exploiting Type II Anion Relay Chemistry (ARC) to provide the full linear carbon and nitrogen skeleton in a single flask with the requisite stereochemistry and functionality. A mechanistic rationale is also proposed to account for the stereochemical outcome of the key aldol reaction leading to the advanced aza tricyclic core.