ol8b02652_si_001.pdf (7.72 MB)
Total Synthesis of Asperphenins A and B
journal contribution
posted on 2018-09-19, 20:47 authored by Jia-Lei Yan, Yingying Cheng, Jing Chen, Ranjala Ratnayake, Long H. Dang, Hendrik Luesch, Yian Guo, Tao YeThe first total synthesis
of asperphenins A and B has been accomplished
in a concise, highly stereoselective fashion from commercially available
materials (15 steps, 9.7% and 14.2% overall yields, respectively).
The convergent route featured the judicious choice of protecting groups,
fragment assembly strategy and a late-stage iron-catalyzed Wacker-type
selective oxidation of an internal alkene to the corresponding ketone.
