ol7b00591_si_003.cif (21.91 kB)
Total Synthesis of (±)-Grandilodine B
dataset
posted on 2017-03-15, 12:48 authored by Chunyu Wang, Zhonglei Wang, Xiaoni Xie, Xiaotong Yao, Guang Li, Liansuo ZuThe
first total synthesis of the opened-type Kopsia alkaloid
grandilodine B is reported. Four stereocenters of this
alkaloid, three of them quaternary, are stereoselectively generated
by a Diels–Alder reaction, a diastereoselective cyanation of
tertiary alcohol, and a facial-selective nitrone 1,3-dipolar cycloaddition.