Total Synthesis and Bioactivity of Some Naturally Occurring Pterulones

W. T. Gruijters, Bas; van Veldhuizen, Albertus; A. G. M. Weijers, Carel; Wijnberg, Joannes B. P. A.

doi:10.1021/np010510m.s001

np010510m_si_001.pdf (81.23 kB)

Total Synthesis and Bioactivity of Some Naturally Occurring Pterulones

journal contribution

posted on 2002-02-19, 00:00 authored by Bas W. T. Gruijters, Albertus van Veldhuizen, Carel A. G. M. Weijers, Joannes B. P. A. Wijnberg

The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorula glutinis and Saccharomyces cerevisiae.