Total Synthesis and Bioactivity of Some Naturally Occurring Pterulones

The naturally occurring pterulones <b>1</b>, <b>3</b>, and <b>13</b> were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (<b>6</b>) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of <i>Rhodotorula </i><i>glutinis</i> and <i>Saccharomyces cerevisiae</i>.