bc9b00661_si_001.pdf (1.62 MB)
Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations
journal contribution
posted on 2019-11-08, 17:03 authored by Jennifer Bouchenna, Magalie Sénéchal, Hervé Drobecq, Jérôme Vicogne, Oleg MelnykOne
hallmark of protein chemical synthesis is its capacity to access
proteins that living systems can hardly produce. This is typically
the case for proteins harboring post-translational modifications such
as ubiquitin or ubiquitin-like modifiers. Various methods have been
developed for accessing polyubiquitin conjugates by semi- or total
synthesis. Comparatively, the preparation of small-ubiquitin-like
modifier (SUMO) conjugates, and more particularly of polySUMO scaffolds,
is much less developed. We describe hereinafter a synthetic strategy
for accessing all SUMO-2/3 dimer combinations.