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Thermoresponsive Block Copolymer Vesicles by Visible Light-Initiated Seeded Polymerization-Induced Self-Assembly for Temperature-Regulated Enzymatic Nanoreactors
journal contribution
posted on 2020-03-23, 13:03 authored by Jun He, Junpeng Cao, Ying Chen, Li Zhang, Jianbo TanBlock copolymer vesicles loaded with
active compounds have been employed as decent candidates to mimic
complex biological systems that attract considerable interest in different
research communities. We herein report a visible light-initiated seeded
reversible addition–fragmentation chain transfer (RAFT)-mediated
polymerization-induced self-assembly (PISA) for in situ preparation
of enzyme-loaded cross-linked block copolymer vesicles without compromising
the bioactivity. Permeability of the vesicular membrane can be regulated
through changing the solution temperature, allowing further control
over the enzymatic reaction rate of enzyme-loaded vesicles. Finally,
non-cross-linked thermoresponsive block copolymer vesicles that can
transform into worm-like micelles at low temperature are also prepared
by this method, allowing the release of bimacromolecules from the
vesicles under mild conditions.
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non-cross-linked thermoresponsive block copolymer vesiclesenzyme-loaded cross-linked block copolymer vesiclesresearch communitiesNanoreactors Block copolymer vesiclesenzyme-loaded vesiclesworm-like micellessolution temperaturereaction ratePISAThermoresponsive Block Copolymer VesiclesVisible Light-Initiated Seeded Polymerization-Induced Self-Assembly
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