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The Mosaic of Rottlerin

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posted on 2015-11-06, 00:00 authored by Kenneth K. C. Hong, Graham E. Ball, David StC. Black, Naresh Kumar
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.

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