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Tandem Isobenzofuran Formation−Diels Alder Reactions in the Coupling of Carbene Complexes with 2-Alkynylbenzaldehyde Derivatives Featuring an Alkyne-Dienophile Tether
journal contribution
posted on 2005-06-20, 00:00 authored by Yumei Luo, James W. HerndonThe coupling of carbene complexes and 2-alkynylbenzaldehyde derivatives has been
examined for systems where the alkyne is further linked to an alkene. This reaction proceeds
via generation of an isobenzofuran followed by a stereoselective intramolecular Diels−Alder
reaction, followed by opening of the resulting oxanorbornene ring. A variety of hydrophenanthrene derivatives and heterocyclic analogues have been produced in this reaction. In one
case the intramolecular Pauson−Khand reaction is a competing process.