jo9b02301_si_001.pdf (3.36 MB)
TBHP/NH4I‑Mediated Direct N–H Phosphorylation of Imines and Imidates
journal contribution
posted on 2019-10-25, 11:04 authored by Xiaofeng Wang, Yingcong Ou, Zhenbo Peng, Guodian Yu, Yuanting Huang, Xianwei Li, Yanping Huo, Qian ChenA direct
and practical metal-free N–H phosphorylation has
been achieved via the TBHP/NH4I-mediated cross-dehydrogenative
coupling (CDC) reactions between imines/imidates and P(O)H compounds.
This transformation provides an efficient synthetic route to the construction
of P–N bonds with good functional group compatibility, leading
to the formation of N-phosphorylimines and N-phosphorylimidates in up to 95% yield (33 examples)
under mild conditions.
