Synthetic and Structural Exploration of Tetrathiacalixarenepyrimidines
2012-10-05T00:00:00Z (GMT) by
A novel class of two atom bridged metacyclophanesthiacalixarenepyrimidineshas been synthesized via a straightforward SNAr reaction. The conformational properties and intra-annular dimensions of the thiacalixarenepyrimidines were evaluated by X-ray structure analysis and compared with known homothia- and thiacalixarenes. Post-macrocyclization oxidation of the bridging sulfur moieties resulted in a sulfonylcalixarenepyrimidine, which gave access to an unexplored cavity size among sulfonylcalixarenes.