Synthesis of the Sialidase Inhibitor Siastatin B

2000-11-17T00:00:00Z (GMT) by Spencer Knapp Dalian Zhao
The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-β-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.