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Synthesis of the Sialidase Inhibitor Siastatin B

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journal contribution
posted on 2000-11-17, 00:00 authored by Spencer Knapp, Dalian Zhao
The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-β-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.

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