jo5005845_si_001.cif (13.88 kB)
Synthesis of N‑(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles
dataset
posted on 2014-07-18, 00:00 authored by Yang Xiong, Xuxue Zhang, Tao Huang, Song CaoA mild and versatile method for the
construction of C–N
bonds by the reaction of (2,2-difluorovinyl)arenes with various N–H-containing
heterocycles in the presence of K3PO4 has been
developed. The reaction proceeded efficiently at room temperature
(25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good
to excellent yields with relatively high stereoselectivity.