ol034771u_si_001.pdf (171.69 kB)
Synthesis of a Nitrogen Analogue of Sphingomyelin as a Sphingomyelinase Inhibitor
journal contribution
posted on 2003-07-09, 00:00 authored by Toshikazu Hakogi, Misako Taichi, Shigeo KatsumuraSphingomyelin nitrogen analogue 1 was designed and synthesized as a sphingomyelinase inhibitor. The synthesis was established by continuous
Hofmann rearrangement and Crutius rearrangement as key steps in constructing the 3-hydroxy-1,2-diamine structure in the backbone of 1.
This analogue showed moderate inhibitory activity toward SMase isolated from B. cereus.