Synthesis of a Naphthyridone p38 MAP Kinase Inhibitor
2006-10-27T00:00:00Z (GMT) by
Compound <b>1 </b>is a p38 MAP kinase inhibitor potentially useful for the treatment of rheumatoid arthritis and psoriasis. A novel six-step synthesis suitable for large-scale preparation was developed in support of a drug development program at Merck Research Laboratories. The key steps include a tandem Heck-lactamization, N-oxidation, and a highly chemoselective Grignard addition of 4-(<i>N</i>-<i>tert</i>-butylpiperidinyl)magnesium chloride to a naphthyridone <i>N</i>-oxide. The <i>N</i>-oxide exerted complete chemoselectivity via chelation in directing the Grignard addition to the α position as opposed to 1,4-addition on the ene-lactam. The dihydropyridyl adduct was in situ aromatized with isobutylchloroformate followed by heating in pyridine. Syntheses of Grignard precursor, <i>N</i>-<i>tert</i>-butyl-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or via addition of methylmagnesium chloride to an iminium ion. Utilizing this chemistry, multi-kilogram preparation of compound <b>1</b> was successfully demonstrated.
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