ol500916g_si_001.pdf (8.06 MB)
Synthesis of α,β-Unsaturated Aldehydes Based on a One-Pot Phase-Switch Dehydrogenative Cross-Coupling of Primary Alcohols
journal contribution
posted on 2014-05-16, 00:00 authored by Manuel
G. Mura, Lidia De Luca, Maurizio Taddei, Jonathan M. J. Williams, Andrea PorchedduAn
efficient one-pot ruthenium-catalyzed hydrogen-transfer
strategy for a direct access to α,β-unsaturated aldehydes
has been developed. The employment of enolates prepared in situ from
alcohols avoided handling unstable aldehydes and provided a very appealing
route to different cinnamaldehydes substituted in position 2. A silica-grafted
amine was used as phase-switch tag leading to a selective one-pot
process in favor of cross-dehydrogenative coupling products.