jo9b00950_si_003.cif (594.47 kB)
Synthesis of Quinolines and Isoquinolines via Site-Selective, Domino Benzannulation of 2- and 3‑Chloropyridyl Ynones with Nitromethane
dataset
posted on 2019-06-14, 00:00 authored by Mallesh Beesu, Goverdhan MehtaAn approach of general applicability
to diverse quinolines and
isoquinolines via a tactic that utilizes the recursive anion from
nitromethane as a 1C-connector to stitch easily and appropriately
crafted pyridyl ynones through a transition-metal-free, tandem Michael
addition–SNAr process is delineated. The straightforwardness,
one-pot operation, and good yields mark this methodology for wider
exploitation in targeting more embellished quinolines and isoquinolines
and complex platforms embodying these moieties.
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moietieSite-SelectivestraightforwardnesNitromethaneapplicability1 C-connectorplatformIsoquinolinemethodologynitromethanetacticChloropyridylapproachSynthesi2-isoquinolinetandemDomino Benzannulationtransition-metal-freeQuinolineyields markanionYnoneexploitationquinolineone-pot operationArpyridyl ynones
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