jo2025543_si_001.pdf (14.79 MB)
Synthesis of Pyrido[1,2-a]indole Malonates and Amines through Aryne Annulation
journal contribution
posted on 2012-03-16, 00:00 authored by Donald
C. Rogness, Nataliya A. Markina, Jesse P. Waldo, Richard C. LarockPyrido[1,2-a]indoles are known as medicinally
and pharmaceutically important compounds, but there is a lack of efficient
methods for their synthesis. We report a convenient and efficient
route to these privileged structures starting from easily accessible
2-substituted pyridines and aryne precursors. A small library of compounds
has been synthesized utilizing the developed method, affording variously
substituted pyrido[1,2-a]indoles in moderate to good
yields.