ol500875e_si_001.pdf (3.93 MB)
Synthesis of Proposed Aglycone of Mandelalide A
journal contribution
posted on 2014-05-16, 00:00 authored by Karla
Mahender Reddy, Vanipenta Yamini, Kiran K. Singarapu, Subhash GhoshA highly
convergent synthesis of the proposed mandelalide A aglycone
is reported. The cornerstones of the synthetic strategy include the
following: E-selective intramolecular Heck cyclization,
Masamune–Roush olefination, Stork–Zhao–Wittig
olefination, modified Prins cyclization; Sharpless asymmetric dihydroxylation
followed by Williamson-type etherification, Julia–Kocienski
olefination, Brown crotylation, and Brown allylation reactions.