jo0625655_si_001.pdf (441.44 kB)
Synthesis of Optically Active Bifunctional Building Blocks through Enantioselective Copper-Catalyzed Allylic Alkylation Using Grignard Reagents
journal contribution
posted on 2007-03-30, 00:00 authored by Anthoni W. van Zijl, Fernando López, Adriaan J. Minnaard, Ben L. FeringaEnantioselective copper-catalyzed allylic alkylations were performed on allylic bromides with a protected
hydroxyl or amine functional group using several Grignard reagents and Taniaphos L1 as a ligand. The
terminal olefin moiety in the products was transformed into various functional groups without racemization,
providing facile access to a variety of versatile bifunctional chiral building blocks.