Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation

An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C–H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation.