Synthesis of Multiring Fused 2‑Pyridones via
a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein
Amyloid Formation

Singh, Pardeep; Chorell, Erik; Krishnan, K. Syam; Kindahl, Tomas; Åden, Jörgen; Wittung-Stafshede, Pernilla; Almqvist, Fredrik

doi:10.1021/acs.orglett.5b03190.s001

ol5b03190_si_001.pdf (8.7 MB)

Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation

journal contribution

posted on 2015-12-18, 00:00 authored by Pardeep Singh, Erik Chorell, K. Syam Krishnan, Tomas Kindahl, Jörgen Åden, Pernilla Wittung-Stafshede, Fredrik Almqvist

An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C–H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation.