jo0c00157_si_001.pdf (6.04 MB)
Synthesis of Lactams via Ir-Catalyzed C–H Amidation Involving Ir-Nitrene Intermediates
journal contribution
posted on 2020-03-06, 13:05 authored by Jitian Liu, Wenjing Ye, Shuojin Wang, Junrong Zheng, Weiping Tang, Xiaoxun Lix-membered lactams
were synthesized via either
an amidation of sp3 C–H bonds or an electrophilic
substitution of arenes via Ir-nitrene intermediates. With the employment
of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol,
a wide range of lactams were synthesized in good to excellent yields
with high selectivity.