jo5b01824_si_001.pdf (1.17 MB)
Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Activation of C(sp3)–H Bond
journal contribution
posted on 2015-11-06, 00:00 authored by Xinying Zhang, Zhangxin Wang, Xuesen Fan, Jianji WangIn
this paper, a novel methodology for the synthesis of ketones
via microwave irradiation promoted direct alkylation of aldehydes
by activation of the inert C(sp3)–H bond has been
developed. Notably, the reactions were accomplished under metal-free
conditions and used commercially available aldehydes and cycloalkanes
as substrates without prefunctionalization. By using this novel method,
an alternative synthetic approach toward the key intermediates for
the preparation of the pharmaceutically valuable oxaspiroketone derivatives
was successfully established.