ja5b08279_si_001.pdf (3.5 MB)
Synthesis of Highly Substituted Racemic and Enantioenriched Allenylsilanes via Copper-Catalyzed Hydrosilylation of (Z)‑2-Alken-4-ynoates with Silylboronate
journal contribution
posted on 2015-12-02, 00:00 authored by Min Wang, Zheng-Li Liu, Xiang Zhang, Pan-Pan Tian, Yun-He Xu, Teck-Peng LohCopper-catalyzed
highly efficient hydrosilylation reaction of enynoates was developed.
Under simple reaction conditions, various di-, tri-, and tetrasubstituted
racemic allene products could be obtained in high yields. The asymmetric
1,6-addition of silyl group to the (Z)-2-alken-4-ynoates
could be achieved under mild reaction conditions to afford the silyl-substituted
enantioenriched chiral allene products in good yields and with high
enantioselectivities.