Synthesis of Highly Substituted 4<i>H</i>‑Pyrido[1,2‑<i>a</i>]pyrimidines via a One-Pot Three-Component Condensation Reaction

A one-pot three-component reaction, involving condensation of 2-aminopyridines, aldehydes, and ketones/aldehydes under trifluoromethanesulfonic acid catalysis, provides rapid access to highly substituted novel 4<i>H</i>-pyrido­[1,2-<i>a</i>]­pyrimidines.