Synthesis of Highly Substituted 4H‑Pyrido[1,2‑a]pyrimidines via a One-Pot Three-Component Condensation Reaction

A one-pot three-component reaction, involving condensation of 2-aminopyridines, aldehydes, and ketones/aldehydes under trifluoromethanesulfonic acid catalysis, provides rapid access to highly substituted novel 4H-pyrido­[1,2-a]­pyrimidines.