jo9b03102_si_001.cif (302.14 kB)
Synthesis of Highly Fused Pyrano[2,3‑b]pyridines via Rh(III)-Catalyzed C–H Activation and Intramolecular Cascade Annulation under Room Temperature
dataset
posted on 2020-02-25, 16:04 authored by Xu Han, Feng Gao, Chunpu Li, Daqing Fang, Xiong Xie, Yu Zhou, Hong LiuA facile access to the polycyclic-fused
pyrano[2,3-b]pyridines has been established under
room temperature via Rh(III)-catalyzed
C–H bond activation and intramolecular cascade annulation.
This strategy features high efficiency, unique versatility, and generality
and it can occur under mild conditions in good to excellent yields.
More importantly, this strategy can be extended to the late-stage
functionalization of drugs possessing the CN group.