Synthesis of Functionalized Pyrroles via Gold(I)-Catalyzed aza-Claisen-Type Rearrangement

2007-08-02T00:00:00Z (GMT) by Florin M. Istrate Fabien Gagosz
Gold(I)-catalyzed cyclization of pentenynyl allyl tosylamides allows the rapid construction of functionalized pyrroles. The concerted aza-Claisen-type mechanism induces a complete selectivity of the process and allows the easy formation of quaternary centers.