jo0c00482_si_001.pdf (3.27 MB)
Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N‑Acyliminium Ions
journal contribution
posted on 2020-03-31, 13:06 authored by Ashley
J. Basson, Mark G. McLaughlinHerein we report our full investigation
into the calcium catalyzed
generation and trapping of N-acyliminium ions from
readily available 3-hydroxyisoindolinones. We have successfully employed
a range of traditional nucleophiles including carbon, nitrogen, and
sulfur containing reactive partners. The reaction is tolerant to a
wide range of functionalities and provides high value scaffolds in
good to excellent yields.