ol070889p_si_001.pdf (132.37 kB)
Synthesis of DEFG Ring of Complestatin and Chloropeptin I: Highly Atropdiastereoselective Macrocyclization by Intramolecular Suzuki-Miyaura Reaction
journal contribution
posted on 2007-06-07, 00:00 authored by Yanxing Jia, Michèle Bois-Choussy, Jieping ZhuPalladium-catalyzed intramolecular Suzuki-Miyaura reaction of linear tripeptide (23) afforded the 16-membered DEFG ring of complestatin (3)
in good yield with an excellent atropdiastereoselectivity. Acidic treatment of 3 triggers a stereospecific rearrangement leading to the corresponding
DEFG ring 4 of chloropeptin I.