American Chemical Society
Browse
ol006510f_si_001.pdf (59.52 kB)

Synthesis of Carbapenam Skeletons Using a Ruthenium-Catalyzed Cyclization

Download (59.52 kB)
journal contribution
posted on 2000-09-13, 00:00 authored by Miwako Mori, Yuji Kozawa, Mayumi Nishida, Makiko Kanamaru, Kiyoko Onozuka, Masanori Takimoto
Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH2CO(PPh3)3 (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.

History