Synthesis of
3,4-Dihydro-2H-1,3,5-thiadiazines

Katritzky, Alan R.; Vakulenko, Anatoliy V.; Xu, Yong-Jiang; Steel, Peter J.

doi:10.1021/jo020033s.s001

jo020033s_si_001.pdf (123.24 kB)

Synthesis of 3,4-Dihydro-2H-1,3,5-thiadiazines

journal contribution

posted on 2002-06-17, 00:00 authored by Alan R. Katritzky, Anatoliy V. Vakulenko, Yong-Jiang Xu, Peter J. Steel

3,4-Dihydro-2H-1,3,5-thiadiazines substituted at the 3 and 6 positions were synthesized by treatment of N-substituted N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-amines with thioamides and zinc bromide in dry CH₂Cl₂ at room temperature for 48−60 h in 48−80% yields.