Synthesis of
2-Aryl-oxazolo[4,5-c]quinoline-4(5H)-ones
and
2-Aryl-thiazolo[4,5-c]quinoline-4(5H)-ones

Hodgetts, Kevin J.; Kershaw, Mark T.

doi:10.1021/ol0350285.s001

ol0350285_si_001.pdf (44.17 kB)

Synthesis of 2-Aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-Aryl-thiazolo[4,5-c]quinoline-4(5H)-ones

journal contribution

posted on 2003-07-08, 00:00 authored by Kevin J. Hodgetts, Mark T. Kershaw

Novel and highly efficient syntheses of oxazolo[4,5-c]quinoline-4(5H)-ones (1) and thiazolo[4,5-c]quinoline-4(5H)-ones (2) from ethyl 2-chlorooxazole-4-carboxylate (4) and ethyl 2-bromo-5-chlorothiazole-4-carboxylate (13), respectively, are described.