ol8b03558_si_001.pdf (4.78 MB)
Synthesis and Utility of 2,2-Dimethyl‑2H‑pyrans: Dienes for Sequential Diels–Alder/Retro-Diels–Alder Reactions
journal contribution
posted on 2018-12-11, 00:00 authored by David Tejedor, Abián Díaz-Díaz, Raquel Diana-Rivero, Samuel Delgado-Hernández, Fernando García-TelladoThe practical use of 2,2-dimethyl-2H-pyrans as
electron-rich dienes in sequential Diels–Alder/retro-Diels–Alder
(DA/rDA) domino processes to generate aromatic platforms has been
demonstrated. Different polysubstituted alkyl 2-naphthoates have been
synthesized by the DA/rDA reaction of benzynes and 2,2-dimethyl-2H-pyrans. The use of other activated alkynes allows the
access of substituted alkyl benzoate derivatives.