posted on 2020-03-09, 20:14authored byAlexandra Bordes, Ana Poveda, Thibault Troadec, Antonio Franconetti, Ana Ardá, Flavie Perrin, Mickaël Ménand, Matthieu Sollogoub, Jerôme Guillard, Jérôme Désiré, Raphaël Tripier, Jesús Jiménez-Barbero, Yves Blériot
A new family of chiral C2 symmetric
tetraazamacrocycles, coined ISAC for IminoSugar Aza-Crown, incorporating
two iminosugars adopting a 4C1 conformation
is disclosed. Multinuclear NMR experiments on the corresponding Cd2+ complex show that the ISAC is a strong chelator in water
and its tetramine cavity adopts a conformation similar to that of
the parent Cd–cyclam complex. Similar behavior is observed
with Cu2+ in solution, with enhanced stability compared
to the Cu–cyclam complex.