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Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles
journal contribution
posted on 2020-03-17, 18:36 authored by Youmei Bao, Shenqi Zhang, Zeming Chen, Ann T. Chen, Junning Ma, Gang Deng, Weiguo Xu, Jiangbing Zhou, Zhi-Qiang Yu, Guangyu Yao, Jianjun ChenBreast
cancer is the most common type of cancer in women. About
12% of all women in the United States will be diagnosed with breast
cancer over their lifetimes. At the same time, incidences of brain
metastases (BMs) are increasing and represent an emerging health threat.
However, there is no effective chemotherapy for breast cancer brain
metastases (BCBMs), which is largely due to lack of efficient delivery
of antitumor drugs or drug combinations to the brain. In this study,
oleanolic acid (OA), a natural pentacyclic triterpenoid compound with
excellent antitumor activity, was found to form nanoparticles (NPs)
and efficiently penetrate the brain for BCBMs treatment. On the basis
of these findings, we developed a synergistic combinatorial chemotherapeutic
regimen by formulating paclitaxel (PTX) into OA NPs and demonstrated
that the resulting PTX-OA NPs effectively inhibited primary breast
cancer and BCBMs in mouse xenografts. Collectively, this study introduces
a new direction to treat primary breast cancer and BCBMs through noninvasive
combination chemotherapy.